Stevens-Johnson Syndrome (SJS) is a rare but life-threatening drug allergy disorder, that causes necrosis of the epidermal cell layer. Almost, all of the individual’s systems like bio-physiological, psychological, socio-cultural, and economic dimensions are affected due to the disease. The aim of nursing care of the patient with SJS is to enhance the patient’s quality of life by anticipating and diagnosing the possible complications early, and taking accurate and appropriate precautions. This review is aimed at providing guidance to the nurses, based on a nursing model of care guidelines for taking care of patients with SJS.