Pain is an unpleasant, emotional and sensory experience arising from any part of the body, associated with a possible tissue damage, and covers all the past experiences of the individual. The severity of urological pain is often associated with its sudden onset. Therefore, local and referred pain management seen associated with the urinary tract is important. This review was studied to discuss the actual approaches and evidence-based practices in the light of the guidelines published by the European Association of Urology (EAU, 2014) in management of urological pain, which indicates itself with severe pain that emerges secondary to surgery, to urological pain syndromes including interstitial cystitis/painful bladder syndrome, urethral pain syndrome, prostatic pain syndrome, scrotal pain syndrome and penile pain syndrome and to stone disease; which is common and negatively aff ecting the patient’s quality of life. Continuous new information obtained for pain management requires for the healthcare professionals to choose the best and most accurate method for patients. Monitoring of the evidence-based clinical practice guidelines plays a key role in achieving this goal.